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Osteoarthritis is the most common disease of joints in adults around the world Felson et al. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage as measured by the level of PROTEINURIA.
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The effectiveness of currently approved drugs for amyotrophic lateral sclerosis ALS is restricted.
. Initial studies have shown ultrahigh-dose methylcobalamin to be a promising agent. In another study 55 PD patients had dyskinesia after 6 years of treatment with levodopa. To validate the efficacy and safety of ultrahigh-dose methylcobalamin for patients with ALS enrolled within 1 year of onset.
Patients having advanced PD symptoms tend to have more dyskinesia. There is a need to develop further treatments. In a study no PD patient with Hoehn and Yahr H and Y stage 1 or 15 had motor complications even after 10 years whereas 60 patients with H and Y stages 4 or 5 had dyskinesia.
Kidney Disease Outcome Quality Initiative 2002 Concepts. Reported that about one-third of all adults have radiological signs of osteoarthritis although Andrianakos et al in an epidemiological study found clinically significant osteoarthritis of the knee hand or hip in only 89 of the adult population 2 3. The most severe form is the end-stage renal disease CHRONIC KIDNEY FAILURE.
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